The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures.
Good Genes Gone Bad highlights seven such colossal failures in drug development-all of which culminated in the development of novel drugs-weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon’s approval of the first biologic drug for breast cancer.
Written by the former R&D head of Biocon, India’s largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.
Catagory: Non Fiction
non fiction main category
Whose Samosa is it Anyway?
In this book, accompany Sonal Ved on a journey of taste through the various timelines across the Indian subcontinent. We go from the banks of the Indus in 1900 bc to the great kingdoms of the north many centuries later; from the time of the Mauryans to when the Mughal Sultanate reigned supreme. Meet the Europeans merchants desperate to trade in Indian treasures, be it the deep-blue indigo or the pricey pepper. On this trip discover answers to such questions as What are the origins of chutney or of the fruit punch, and how are they connected to India? Who taught us how to make ladi pav and kebabs, and how did the Burmese khow suey land up on the wedding menus of Marwaris? The author takes us through the food history and traditions from the mountains in Kashmir to the backwaters of Kanyakumari; from the ports of the Bay of Bengal to the shores of the Arabian Sea, where traders and travellers arrived from the world over. And, finally, we find out whose samosa it truly is . . .
The Home Stretch
In their twilight years, people increasingly rely on friends and family to get through the day. In Indian homes, it is not unusual to see adult children sandwiched between parenting and caregiving obligations, with both young children and elderly parents in the house.
The Home Stretch is an empathetic, handy guide that seeks to simplify caregiving and equip readers with the tools
and guidance required to build a safer, happier and more comfortable life for the elders around them. From tips on
maintaining their health and independence to taking care of the bedridden, the book covers a wide range of topics
to meet the progressively complicated needs associated with caring for ageing loved ones.
A product of the author’s years of caregiving experience and interactions with countless doctors, counsellors, senior
citizens and other family caregivers, this book has the ability to transform how we look at ageing and the aged.
Invisible Empire
Viruses are the world’s most abundant life form, and now, when humanity is in the midst of a close encounter with their immense power, perhaps the most feared. But do we understand viruses? Possibly the most enigmatic of living things, they are sometimes not considered a life form at all. Everything about them is extreme, including the reactions they evoke. However, for every truism about viruses, the opposite is also often true. So complex and diverse is the world of viruses that it merits being labelled an empire unto itself. And whether we see them as alive or dead, as life-threatening or life-affirming, there is an ineluctable beauty, even a certain elegance, in the way viruses go about their lives-or so Pranay Lal tells us in Invisible Empire: The Natural History of Viruses.
This is a book that defies categorisation. It brings together science, history and great storytelling to paint a fascinating picture of viruses as a major actor, not just in human civilisation but also in the human body. With rare photographs, paintings, illustrations and anecdotes, it is a magnificent and an extremely relevant book for our times, when we are attempting to understand viruses and examining their role in the lives of humans.
The Great Gatsby (PREMIUM PAPERBACK, PENGUIN INDIA)
Welcome to the roaring twenties, where money, debauchery, and dancing go hand-in-hand. It is the summer of 1922,and the enigmatic millionaire, Jay Gatsby, is in love. He has everything he could ever want, except the one thing that always remains out of reach-the beautiful socialite Daisy Buchanan, a former lover, now married to someone else.
At his Long Island mansion, he throws lavish parties-drowning days and nights into drinks and dancing. But all the money in the world cannot fill the emptiness in his heart.
Alone, untouched by the glitz and glamour of the American rich, he stews in his secret longing. But everything changes when Gatsby befriends Nick Carraway, Daisy’s cousin and Gatsby’s new neighbour, who reunites the two lovers. Then begins a tale of obsession, madness, and tragedy that unravels Jay Gatsby’s life forever.
Economist Gandhi
Examining Mahatma Gandhi through an unconventional lens, this book is an original and thought-provoking contribution to Gandhian literature. A refreshing take on the Mahatma’s economic philosophy, Economist Gandhi tells us why we need to look at him as an unlikely management guru and an original thinker who enriched the discourse around market capitalism. The book explains Gandhi’s positive approach towards business: even though he greatly reduced his individual wants, he was against poverty and wanted every Indian to enjoy a materially comfortable life.
Economist Gandhi is probably the first book on Gandhi that claims that he was not against business and capitalists. It not only provides insights into a hidden facet of Gandhi’s personality-his thoughts on economics and capitalism-but also enlightens the reader about some of Gandhi’s views on religion, ethics, human nature, education and society. The book unveils a Gandhi who is brilliant, daring and, most importantly, distinctive.
The Nutmeg’s Curse
Before the 18th century, every single nutmeg in the world originated around a group of small volcanic islands east of Java, known as the Banda Islands. As the nutmeg made its way across the known world, they became immensely valuable – in 16th century Europe, just a handful could buy a house. It was not long before European traders became conquerors, and the indigenous Bandanese communities – and the islands themselves – would pay a high price for access to this precious commodity. Yet the bloody fate of the Banda Islands forewarns of a threat to our present day.
Amitav Ghosh argues that the nutmeg’s violent trajectory from its native islands is revealing of a wider colonial mindset which justifies the exploitation of human life and the natural environment, and which dominates geopolitics to this day.
Written against the backdrop of the pandemic and the Black Lives Matter protests, and interweaving discussions on everything from climate change, the migrant crisis, and the animist spirituality of indigenous communities around the world, The Nutmeg’s Curse offers a sharp critique of Western society, and reveals the profoundly remarkable ways in which human history is shaped by non-human forces.
The Dream of Revolution
Few figures in modern India have enjoyed such acclaim and adoration as Jayaprakash Narayan. And yet, he has been equally vilified for all that went wrong in the unfinished post-colonial movement for freedom and democracy. Jayaprakash Narayan, or JP as he was universally known, epitomized the Marxian and Gandhian styles of political engagement, and famously brought a powerful government to its knees. Throughout his life, he channelled an emotional hunger for transformative politics, jettisoned easy options, shunned power and incubated revolutionary ideas.
A comprehensive study of JP’s life and ideas-from the radicalism of his thought process at American university campuses in the 1920s to his political coming of age in the 1930s and subsequent disenchantment with Gandhi’s leadership; from his infectious confidence about the future of socialism to his seemingly naive plans to outmanoeuvre powerful forces within the Congress; from his fractious friendship with Jawaharlal Nehru to his relentless crusade against the stifling of dissent-The Dream of Revolution, Bimal and Sujata Prasad’s rigorously researched biography of JP, dispenses with clichés, questions commonly held perceptions and pushes the limits of what a biographical portrait is capable of.
Rich in anecdotes and never-before-told stories, this book explores the ambiguities and ironies of a life lived at the barricades, and one man’s unremitting quest to usher in a society based on equality and freedom.
Burning Bright
The true story of the ‘Iron Lady of Manipur’ who fasted for 16 years against AFSPA
Ten innocent people were mowed down by security forces in Malom, a village near Imphal, in November 2000. The perpetrators were not punished, protected under the Armed Forces Special Powers Act which empowers military and para-military personnel to arrest, shoot, even kill, anyone on the grounds of mere suspicion. In response to this tragedy–one among many such atrocities–Irom Sharmila, a young Manipuri, began an indefinite hunger strike. The government arrested her and force-fed her through nasal tubes. She was released and re-arrested innumerable times, but she stood by her demand. In July 2016, Irom brought her sixteen years of hunger strike to an end, and decided to contest the elections.
Burning Bright is a hard-hitting account of a people caught between the crossfire of militants and security forces; of a once-sovereign kingdom whose culture has been brutally violated; of the many voices of dissent-from underground groups to the Meira Paibis, a women’s movement opposed to all forms of violence whether by the state or insurgents and a moving portrait of ‘the Iron Lady of Manipur’.
Kathmandu Dilemma
‘…unmatched in its meticulous and careful research into the wellsprings of a truly unique relationship between two neighbouring states.’ SHYAM SARAN
‘Ranjit Rae’s portrayal of India-Nepal relations from the Indian perspective is meticulous, nuanced and insightful.” S.D. MUNI
‘Ranjit Rae breaks down the paradox of India’s very intimate yet troubled relationship with Nepal.’ C. RAJA MOHAN
The first two decades of the new millennium have witnessed a dramatic socio-political transformation of Nepal. A violent Maoist insurgency ended peacefully, a new constitution abolished the monarchy and established a secular federal democratic republic. Nevertheless, political stability and a peace dividend have both remained elusive. Nepal is also buffeted by changing geopolitics, including the US-China contestation for influence and the uneasy relationship between India and China.
As a close neighbour, India has been deeply associated with the seminal changes in Nepal, and the bilateral relationship has seen many twists and turns. Partly a memoir, this book examines India’s perspective on these developments, in the context of the civilizational and economic underpinnings of the India-Nepal relationship, as well as issues that continue to prevent this relationship from exploiting its full potential. Though there are several Nepalese accounts that deal with this subject, there are few from an Indian point of view. Kathmandu Dilemma fills this gap.